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Users Guide and clinical case studies
The clinical situation of patients who have benefited from treatment with Ubigel Inperio visibly improves after just one application.
Patients interviewed one week after the first application reported having noticed an improvement in their gum conditions, less bleeding, less pain when brushing and less redness.
Prof. ssa Casu
Conservative management of inflammatory epulis: combined treatment with photodynamic therapy and periodontal gel.
Inflammatory epulis is a benign reactive lesion cthat affects the gingival tissue, often linked to chronic irritative factors, including plaque and tartar.
It affects young women more frequently, especially during pregnancy, as its onset is also linked to hormonal factors.
Prof. ssa Roncati
How to Enhance the Effectiveness of Etiological Therapy Through the Use of a Biomaterial
The clinical case presented illustrates the use of a biomaterial (Ubigel Inperio, Pierrel) as an adjunct to non-surgical etiological therapy in a patient with localized periodontitis. It highlights the benefits of an integrated treatment approach based on accurate diagnosis, appropriate instrumentation, targeted application of the biomaterial, and continuous patient motivation provided by the entire dental team.
Spermidine is a natural low molecular weight polyamine widely distributed in various organisms.
It has a high capacity to promote the reparative effect of periodontal, bone and dental tissue damaged by the erosive effects of periodontitis.
The structural feature is crucial for its functions, which include DNA stabilization, promotion of cell growth, and induction of autophagya.
Cells 2025, 14, 1047
SMorphological and Molecular Evaluation of a Gel Based on Hyaluronic Acid and Spermidine for Oral Regenerative Purposes.
Dolaji Henin, Elena Canciani, Daniela Carmagnola, Stefano Ferrero, Gaia Pellegrini, Mariachiara Perrotta, Riccardo Sirello, Claudia Dellavia, and Nicoletta Gagliano
Clinical Oral Investigations (2024) 28:537
Treatment of peri-implant mucositis using spermidine and calcium chloride as local adjunctive delivery to non-surgical mechanical debridement: a double-blind randomized controlled clinical trial.
Vincenzo Iorio-Siciliano · Dario Marasca · Leopoldo Mauriello · Enzo Vaia · Stefan-Ioan Stratul · Luca Ramaglia
CPQ Dentistry (2019) 1:4 Research Article
Spermidine Associated to Non-Surgical Treatment of Periodontal
Disease: Split Mouth Randomized Controlled Clinical Trial.
Daniela Carmagnola · Carlo Angelo Ghisalberti · Gaia Pellegrini · Lucrezia Cinquanta · Marilisa Toma & Claudia Dellavia
Ubigel activates the mechanistic action of the connective tissue cells by stimulating the exchange and production of proteins that promote cellular activities for the well-being of the periodontist without altering its morphology and inducing the healing of the gums from the periodontitis.
